Pope Whitney B. (ed.) Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches

Springer, 2020. — 986 p. — ISBN 978-3-030-27359-0.This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed.Indications and Limitations of Conventional Imaging – Current Clinical Practice in the Context of Standard Therapy
Surrogates for Disease Status: Contrast Enhancement Including Limitations of Pseudoprogression and Pseudoresponse
The Relationship Between Biological and Imaging Characteristics in Enhancing and Nonenhancing Glioma
Contrast-Enhanced T1-Weighted Digital Subtraction for Increased Lesion Conspicuity and Quantifying Treatment Response in Malignant Gliomas
Advanced Physiologic Imaging: Perfusion – Theory and Applications
Advanced Physiologic Imaging: Diffusion – Theory and Applications
Parametric Response Map (PRM) Analysis Improves Response Assessment in Gliomas
Review of WHO 2016 Changes to Classification of Gliomas; Incorporation of Molecular Markers
Imaging Markers of Lower-Grade Diffuse Glioma
CEST, pH, and Glucose Imaging as Markers for Hypoxia and Malignant Transformation
MRS for D-2HG Detection in IDH-Mutant Glioma
C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain Tumors
FET and FDOPA PET Imaging in Glioma
Imaging Genomics
Radiomics and Machine Learning
Immunotherapy and Gliomas
The Path Forward: The Standardized Brain Tumor Imaging Protocol (BTIP) for Multicenter Trials